Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer.

Cancer discovery - 1 Jun 2026

Hong Jungeui, Kohutek Zachary A, Zhang Haochen, Lecomte Nicolas, Karnoub Elias-Ramzey, Kappagantula Rajya, Wood Laura D, O'Reilly Eileen M, Reyngold Marsha, Crane Christopher H, Iacobuzio-Donahue Christine A

Abstract excerpt

We performed whole-exome sequencing of 250 unique tumor tissues from 30 multi-region sampled pancreatic cancer research autopsies from patients diagnosed with advanced-stage disease. Convergent evolution within the TGFβ pathway is a common feature of advanced-stage disease. However, SMAD4 inactivation is more common among de novo metastatic pancreatic ductal adenocarcinomas (PDAC), whereas inactivation of TGFβ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Neoadjuvant Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organoids

Share to Pancreatectomy

Share to Receptor, Transforming Growth Factor-beta Type II

Share to Smad4 Protein

Share to Transforming Growth Factor beta

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 41650466
DOI: 10.1158/2159-8290.CD-24-0772
PMCID: PMC13223546

Genes

SMAD4
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer.PMID 41650466Read ↗

Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic CancerSemantic proximity Read ↗

SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition.Semantic proximity Read ↗

Alteration of Transforming Growth Factor β Signaling Pathway Predicts Worse Prognosis in Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Cross-species single-cell atlases chart progression, therapy-driven remodelling and immune evasion in pancreatic cancerSemantic proximity Read ↗

ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients.Semantic proximity Read ↗

Pathway-specific genomic alterations in pancreatic cancer across diverse cohortsSemantic proximity Read ↗

Pancreas Cancer Precision Treatment Using Avatar Mice from a Bioinformatics PerspectiveSemantic proximity Read ↗

Ecoevolutionary biology of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Whole Exome Sequencing of Rapid Autopsy Tumors and Xenograft Models Reveals Possible Driver Mutations Underlying Tumor ProgressionSemantic proximity Read ↗

Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter?Semantic proximity Read ↗

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.