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Article

Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells.

Scientific reports - 18 Feb 2024

Lodge Mareca, Scheidemantle Grace, Adams Victoria R, Cottam Matthew A, Richard Daniel, Breuer Denitra, Thompson Peter, Shrestha Kritika, Liu Xiaojing, Kennedy Arion

Abstract excerpt

Over-consumption of fructose in adults and children has been linked to increased risk of non-alcoholic fatty liver disease (NAFLD). Recent studies have highlighted the effect of fructose on liver inflammation, fibrosis, and immune cell activation. However, little work summarizes the direct impact of fructose on macrophage infiltration, phenotype, and function within the liver. We demonstrate that chronic fructose...

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Identifiers

PMID: 38369593
DOI: 10.1038/s41598-024-54272-w
PMCID: PMC10874942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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