Article

SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon

2025-04-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction</bold> The potential roles of fructose in colon cancer are growing concerns. Fructose consumption has been linked to oxidative stress and mitochondrial dysfunction, yet its specific molecular mechanisms in colon carcinogenesis remain underexplored. <bold>Objectives</bold> This study aimed to investigate the molecular mechanisms by which dietary fructose contribut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a0badf9-79b3-5b0b-add2-d3715f4af9f4
DOI: 10.21203/rs.3.rs-6226269/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colonDOI 10.21203/rs.3.rs-6226269/v1Read

Dietary Fructose Suppresses Hepatocellular Carcinogenesis through Fructose 1-Phosphate-Mediated Inhibition of Mannose Phosphate IsomeraseSemantic proximity Read

Sex Differences in Dietary Copper-Fructose Interaction-Induced Alterations of Gut Microbial Activity are Not Correlated to Hepatic SteatosisSemantic proximity Read

Potential role of fructose on human colon DNA methylation in racial disparities observed for colorectal cancer riskSemantic proximity Read

Effect of Aberrant Fructose Metabolism Following SARS-CoV-2 Infection on Colorectal Cancer Patients' Poor PrognosisSemantic proximity Read

Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.Semantic proximity Read

The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights.Semantic proximity Read

Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathwaySemantic proximity Read

Pan-cancer analysis of UDP-glucose 6-dehydrogenase and its carcinogenesis in hepatocellular carcinomaSemantic proximity Read

Dietary copper-fructose interactions alter gut microbial activity in male ratsSemantic proximity Read

Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models.Semantic proximity Read

Refined fructose and cancerSemantic proximity Read

UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancerSemantic proximity Read