Article

Sirt2-SUMOylation is essential for its tumor-suppressor function in neuroblastoma

2020-09-08

Abstract excerpt

<title>Abstract</title> <p>Background SUMOylation is an important post-translational modification and participates in a variety of cellular physiological and pathological processes in eukaryotic cells. Sirt2, as a NAD<sup>+</sup>-dependent deacetylase, usually exerts tumor-suppressor function. However, its SUMOylation roles in cancer cells have not been illustrated. Methods Ni<sup>2+</sup>-NTA, GST-pull down an...

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Literature Corpus work: 398308f6-644b-5701-a17b-f491a0dcbe02
DOI: 10.21203/rs.3.rs-68879/v1

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