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Article

SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma

11 Dec 2020

Abstract excerpt

SUMOylation is an important post-translational modification that participates in a variety of cellular physiological and pathological processes in eukaryotic cells. Sirt2, a NAD+-dependent deacetylase, usually exerts a tumor-suppressor function. However, the role of SUMOylation in cancer cells is not fully known. In this study, we found that SUMOylation can occur in the Sirt2 protein at both lysine 183 and lysine...

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PMID: 33316537
DOI: 10.1016/j.neo.2020.11.013

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