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Article

The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?

8 Sept 2020

Abstract excerpt

Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase (HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a number of non-histone proteins and plays a pivotal role in various physiologic processes. Previously, SIRT2 has been considered indispensable during carcinogenesis; however, there is now a significant controversy regarding whether...

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Identifiers

PMID: 33014852
DOI: 10.3389/fonc.2020.01721

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