Article

Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy

2021-07-26

Abstract excerpt

Oncogene-induced replication stress is a major driver of genomic instability in cancer cells, with a central role in both cancer initiation and progression (1). Despite its critical role in cancer development, the mechanisms that lay at the basis of oncogene-induced replication stress remains poorly understood. Here, we investigate the mechanism of c-Myc-induced replication stress. Our data shows that c-Myc induce...

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Literature Corpus work: 331bf6fa-94e3-5b5c-aa13-35c859684653
DOI: 10.1101/2021.07.25.453647

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