Article

A developmentally regulated long-range enhancer-promoter contact mediates human neural development

2025-12-03

Abstract excerpt

<h4>SUMMARY</h4> SOX2 is a core pluripotency factor in human embryonic stem cells (hESCs), but upon differentiation to the three germ layers, its expression is preserved selectively in neuroectoderm. The mechanisms regulating SOX2 transcription in distinct developmental stages remain incompletely understood. Here, we demonstrate that a distant enhancer 550 kb from the human SOX2 locus is selectively activated i...

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Literature Corpus work: 394a8597-e9c3-50d4-ada8-de6045f81f5a
DOI: 10.64898/2025.12.01.691702

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