Article
A distant global control region is essential for normal expression of anterior <i>HOXA</i> genes during mouse and human craniofacial development
2022-03-11
Abstract excerpt
Defects in embryonic patterning resulting in craniofacial abnormalities account for approximately 1/3 of birth defects. The regulatory programs that build and shape the face require precisely controlled spatiotemporal gene expression, achieved through tissue-specific enhancers. Large regions with coactivation of enhancer elements and co-regulation of multiple genes, referred to as superenhancers, are important in...
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Identifiers and source
- Literature Corpus work
- 841bf907-0061-578e-af85-b49d2be7a83e
- DOI
- 10.1101/2022.03.10.483852