Article

Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

2022-03-27

Abstract excerpt

Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted inhibition of Foxo1. We have shown that this can be achieved by genetic ablation in gut Neurogenin3 progenitors, adenoviral or shRNA-mediated inhibition in human gut organoids, and c...

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Identifiers and source

Literature Corpus work: 392d7467-eeff-58c8-a814-d6b783e5931c
DOI: 10.1101/2022.03.26.485929

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Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic miceDOI 10.1101/2022.03.26.485929Read

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