Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagy

24 Apr 2025

Abstract excerpt

BACKGROUND Type 2 diabetes mellitus (T2DM) is a severe global health problem that causes prolonged disease exposure and an elevated risk for chronic complications, posing a substantial health burden. Although therapies, such as GLP-1 receptor agonists and SGLT2 inhibitors, have been successfully developed, new therapeutic options are still expected to offer better blood glucose control and decrease complications....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to Pancreatic function and diabetes
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40487620
DOI: 10.4239/wjd.v16.i5.102994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TERT/FOXO1 signaling promotes islet β-cell dysfunction in type 2 diabetes mellitus by regulating ATG9A-mediated autophagyPMID 40487620Read ↗

The role of autophagy in the treatment of type II diabetes and its complications: a reviewSemantic proximity Read ↗

Dysregulation of pancreatic β-cell autophagy and the risk of type 2 diabetesSemantic proximity Read ↗

β-Cell Autophagy in Diabetes PathogenesisSemantic proximity Read ↗

Autophagy: Playing an important role in diabetes and its complicationsSemantic proximity Read ↗

Pancreas Β-Cells in Type 1 and Type 2 Diabetes: Cell Death, Oxidative Stress and Immune Regulation. Recently Appearing Changes in Diabetes ConsequencesSemantic proximity Read ↗

Role of islet β cell autophagy in the pathogenesis of diabetesSemantic proximity Read ↗

Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genesSemantic proximity Read ↗

Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative StressSemantic proximity Read ↗

Research progress on the relationship between autophagy and chronic complications of diabetesSemantic proximity Read ↗

Pathophysiology of type 2 diabetes: targeting islet cell dysfunction.Semantic proximity Read ↗

KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein ResponseSemantic proximity Read ↗

Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.