Article

Deep mutational scanning of a multi-domain signaling protein reveals mechanisms of regulation and pathogenicity

2024-05-13

Abstract excerpt

Multi-domain signaling enzymes are often regulated through extensive inter-domain interactions, and disruption of inter-domain interfaces by mutations can lead to aberrant signaling and diseases. For example, the tyrosine phosphatase SHP2 contains two phosphotyrosine recognition domains that auto-inhibit its catalytic domain. SHP2 is canonically activated by binding of these non-catalytic domains to phosphoprotein...

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Literature Corpus work: c7122ce0-ae72-5e98-ab8f-085dd813bc7d
DOI: 10.1101/2024.05.13.593907

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