Article

AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administration

2025-02-04

Abstract excerpt

Adeno-associated virus (AAV) vectors are pivotal in gene therapy for neurological disorders due to their ability to enable long-term gene expression in the central nervous system (CNS). However, transducing larger brains, such as those of non-human primates (NHPs), remains challenging, necessitating alternative delivery routes and optimized capsids. This study directly compares the transduction efficiency and biod...

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Literature Corpus work: d623e74d-113b-5c6d-9b56-5ea3b6d81ad6
DOI: 10.1101/2025.02.04.636515

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AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administrationDOI 10.1101/2025.02.04.636515Read

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