Article

Sibling Variation in Phenotype and Genotype: Polygenic Trait Distributions and DNA Recombination Mapping with UK Biobank and IVF Family Data

2022-09-19

Abstract excerpt

We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to investigate sibling variation in both phenotype and genotype. We compare phenotype (disease status, height, blood biomarkers) and genotype (polygenic scores, polygenic health index) distributions among siblings to those in the general population. As expected, the between-siblings standard deviation in polygenic scores is times small...

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Literature Corpus work: 38c6d472-b6ad-560a-8ae0-0ef0a236e064
DOI: 10.1101/2022.09.17.22280057

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