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Article

Sibling variation in polygenic traits and DNA recombination mapping with UK Biobank and IVF family data.

Scientific reports - 7 Jan 2023

Lello Louis, Hsu Maximus, Widen Erik, Raben Timothy G

Abstract excerpt

We use UK Biobank and a unique IVF family dataset (including genotyped embryos) to investigate sibling variation in both phenotype and genotype. We compare phenotype (disease status, height, blood biomarkers) and genotype (polygenic scores, polygenic health index) distributions among siblings to those in the general population. As expected, the between-siblings standard deviation in polygenic scores is [Formula:...

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Identifiers

PMID: 36611071
DOI: 10.1038/s41598-023-27561-z
PMCID: PMC9825593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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