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Radiation Induced Checkpoint Immunotherapy Response in Refractory Colorectal and Pancreatic Adenocarcinoma

2020-09-01

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade has limited efficacy in microsatellite stable (MSS) colorectal (CRC) and pancreatic (PDAC) cancer. Preclinical models have demonstrated the use of radiation to activate the innate immune response and stimulate responsiveness to immune checkpoint blockade. Here, we describe a Phase 2 trial of radiation therapy combined with combined anti-CTLA4 (ipilimumab) and...

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Literature Corpus work
38b3520d-5be3-5cc7-bf97-8cecf22cf80a
DOI
10.21203/rs.3.rs-58489/v1
Open publication

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Radiation Induced Checkpoint Immunotherapy Response in Refractory Colorectal and Pancreatic AdenocarcinomaDOI 10.21203/rs.3.rs-58489/v1
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