Article

Combinatorial delivery of low-dose irradiation and immunotherapy to patients with immune-excluded tumors effectively enhances CD8<sup>+</sup>T cell functionality

2025-05-12

Abstract excerpt

Immune-checkpoint blockade (ICB) has shown significant efficacy across various tumor types. However, tumors with low intraepithelial T-cell infiltration, often referred to as “cold” tumors, are expected to yield poor responsiveness to ICB. We investigated the potential of low-dose radiotherapy (LDRT) to enhance ICB responses in 25 patients with multimetastatic immune-excluded solid tumors through a multi-cohort ph...

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Literature Corpus work: 967da7f1-6e51-55c2-aa70-f0f3f24f2ad6
DOI: 10.1101/2025.05.12.25327418

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Combinatorial delivery of low-dose irradiation and immunotherapy to patients with immune-excluded tumors effectively enhances CD8<sup>+</sup>T cell functionalityDOI 10.1101/2025.05.12.25327418Read

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