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Study Protocol of A Phase II Study to Evaluate Safety and Efficacy of Neo-adjuvant Pembrolizumab and Radiotherapy in Localized Rectal Cancer

2021-11-01

Abstract excerpt

<h4>Background</h4> Reshaping the tumor microenvironment by novel immunotherapies represents a key strategy to improve the treatment of cancers. Nevertheless, responsiveness to these treatments is often correlated with the extent of the T cell infiltration at the tumor site. Remarkably, microsatellite stable rectal cancer is characterized by poor infiltration and, therefore, do not respond to immune checkpoint blo...

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Literature Corpus work
3215dd99-2f33-5240-af10-0071502f879c
DOI
10.1101/2021.10.31.21265647
Open publication

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