Article

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

2021-07-02

Abstract excerpt

Analyses of genetic variation in many taxa have established that neutral genetic diversity is shaped by natural selection at linked sites. Whether the mode of selection is primarily the fixation of strongly beneficial alleles (selective sweeps) or purifying selection on deleterious mutations (background selection) remains unknown, however. We address this question in humans by fitting a model of the joint effects...

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Literature Corpus work: 38b26d79-ad04-5b74-8021-dc1c81fe0cfb
DOI: 10.1101/2021.07.02.450762

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