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Article

Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes.

Genome research - 1 Sept 2005

Reed Floyd A, Akey Joshua M, Aquadro Charles F

Abstract excerpt

The roles of positive directional selection (selective sweeps) and negative selection (background selection) in shaping the genome-wide distribution of genetic variation in humans remain largely unknown. Here, we optimize the parameter values of a model of the removal of deleterious mutations (background selection) to observed levels of human polymorphism, controlling for mutation rate heterogeneity by using...

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Identifiers

PMID: 16140989
DOI: 10.1101/gr.3413205
PMCID: PMC1199535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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