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The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An Overview

12 Oct 2018

Abstract excerpt

Receptor tyrosine kinases (RTKs) regulate cellular processes by converting signals from the extracellular environment to the cytoplasm and nucleus. Tyro3, Axl, and Mer (TAM) receptors form an RTK family that plays an intricate role in tissue maintenance, phagocytosis, and inflammation as well as cell proliferation, survival, migration, and development. Defects in TAM signaling are associated with numerous...

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PMID: 30322068
DOI: 10.3390/cells7100166

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