Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.

The EMBO journal - 1 Dec 2010

Caberoy Nora B, Zhou Yixiong, Li Wei

Abstract excerpt

Tubby and tubby-like protein 1 (Tulp1) are newly identified phagocytosis ligands to facilitate retinal pigment epithelium (RPE) and macrophage phagocytosis. Both proteins without classical signal peptide have been demonstrated with unconventional secretion. Here, we characterized them as novel MerTK ligands to facilitate phagocytosis. Tulp1 interacts with Tyro3, Axl and MerTK of the TAM receptor tyrosine kinase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Amino Acid Motifs
Share to c-Mer Tyrosine Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Macrophages

Share to Myosin Type II

Share to Phagocytosis

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 20978472
DOI: 10.1038/emboj.2010.265
PMCID: PMC3020645

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.PMID 20978472Read ↗

TAM receptors in phagocytosis: Beyond the mere internalization of particlesSemantic proximity Read ↗

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteinsSemantic proximity Read ↗

MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian FolliclesSemantic proximity Read ↗

Unconventional secretion of tubby and tubby-like protein 1.Semantic proximity Read ↗

Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.Semantic proximity Read ↗

Teleost leukocyte immune-type receptors activate distinct phagocytic modes for target acquisition and engulfment.Semantic proximity Read ↗

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and ActivationSemantic proximity Read ↗

Efficient identification of tubby‐binding proteins by an improved system of T7 phage displaySemantic proximity Read ↗

TAM receptors in apoptotic cell clearance, autoimmunity, and cancerSemantic proximity Read ↗

A Comprehensive Review of Mutations in the MERTK Proto-Oncogene.Semantic proximity Read ↗

Cell surface receptors TREM2, CD14 and integrin α <sub>M</sub> β <sub>2</sub> drive sinking engulfment in phosphatidylserine-mediated phagocytosisSemantic proximity Read ↗

A role for the Tubby-like protein 1 in rhodopsin transport.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.