Article

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

2022-03-02

Abstract excerpt

The ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification of both effective targets for local immune-modulation and a delivery system capable of crossing the blood-brain-barrier. The recent identification and characterization of a small population of regulatory T cells (Tregs) r...

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Literature Corpus work: 38a1abf6-e999-59c2-8f89-2bf22396cb47
DOI: 10.1101/2022.02.28.482297

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