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Article

P2Y12-targeted modulation of microglial phenotypes: A novel therapeutic strategy for enhanced axonal regeneration post-spinal cord injury.

Life sciences - 15 Nov 2024

Zhang Kai, Wen Runlin, Ma Wanrong, Ji Huaqing, He Xinghui, Yang Zhiquan, Liu Dingyang, Li Xing

Abstract excerpt

AIMS: Microglia activation after spinal cord injury (SCI) is a double-edged sword, modulation of the activated microglia populations toward pro-regenerative phenotypes highlights the potential therapeutic implications. P2Y12, a microglia-specific marker, remains underexplored in its capacity to polarize microglial activation populations in SCI repair. We aimed to explore the effects of modulating P2Y12 on...

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Identifiers

PMID: 39277132
DOI: 10.1016/j.lfs.2024.123057

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