Article

Beyond Quiescent and Active: Intermediate Microglial Transcriptomic States in a Mouse Model of Down Syndrome

2024-02-05

Abstract excerpt

Research on microglia in Down syndrome (DS) has shown that microglial activation, increased inflammatory gene expression, and oxidative stress occur at different ages in DS brains. However, most studies resulted in simplistic definitions of microglia as quiescent or active, ignoring potential intermediate states. However, a recent work on microglial cells in young DS brains indicated that those evolve through diff...

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Literature Corpus work: 3895b557-2f44-5bec-a14c-0124fa3c08a0
DOI: 10.20944/preprints202402.0220.v1

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