Article

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

2023-05-11

Abstract excerpt

Genome-wide association studies have unearthed a wealth of genetic associations across many complex diseases. However, translating these associations into biological mechanisms contributing to disease etiology and heterogeneity has been challenging. Here, we hypothesize that the effects of disease-associated genetic variants converge onto distinct cell type specific molecular pathways within distinct subgroups of...

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Literature Corpus work: 38953159-927b-56d9-bbf9-e68e357fd93e
DOI: 10.1101/2023.05.10.23289788

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