Article
Distinct genetic liability profiles define clinically relevant patient strata across common diseases.
Nature communications - 1 Jul 2024
Trastulla Lucia, Dolgalev Georgii, Moser Sylvain, Jiménez-Barrón Laura T, Andlauer Till F M, von Scheidt Moritz, Budde Monika, Heilbronner Urs, Papiol Sergi, Teumer Alexander, Homuth Georg, Völzke Henry, Dörr Marcus, Falkai Peter, Schulze Thomas G, Gagneur Julien, Iorio Francesco, Müller-Myhsok Bertram, Schunkert Heribert, Ziller Michael J
Abstract excerpt
Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor profiles to deconstruct clinical heterogeneity. Contemporary approaches to this problem rely on polygenic risk scores (PRS), which provide only limited clinical utility and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.