Article

Chemosensitivity associated chromatin conformation changes and genomic cisplatin-DNA adduct distribution

2020-01-01

Abstract excerpt

Epigenetic changes are associated with the emergence of resistance to DNA damaging, anti-cancer drugs, such as cisplatin; widely used in the treatment of ovarian cancer. However, how chromatin conformation changes during the acquisition of resistance and how this influences cisplatin-DNA adduct formation are poorly understood. We have investigated chromatin conformation in matched sensitive and resistant ovarian c...

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Literature Corpus work: 389454bc-c6dc-55d4-88f0-ddd4fb64e322
DOI: 10.25560/81726

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