Article

The epigenetic response to platinum-induced DNA damage and repair

2016-01-01

Abstract excerpt

Platinum resistance causes treatment failure in a variety of cancers including ovarian cancer. Epigenetic changes can contribute to platinum resistance, as the epigenome is highly divergent between platinum-resistant and -sensitive cells, and DNA demethylating agents partially resensitise resistant cells to platinum. The mismatch repair (MMR) gene MLH1 is epigenetically silenced in certain ovarian cisplatin-resist...

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Literature Corpus work: d75cb09d-a8fc-5394-a1f4-4f2ae12f13af
DOI: 10.25560/56682

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