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Article

Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer.

Clinical epigenetics - 28 Aug 2021

Soto Javier Andrés, Rodríguez-Antolín Carlos, Vera Olga, Pernía Olga, Esteban-Rodríguez Isabel, Dolores Diestro Maria, Benitez Javier, Sánchez-Cabo Fátima, Alvarez Rafael, De Castro Javier, Ibanez de Cáceres Inmaculada

Abstract excerpt

BACKGROUND: In an effort to contribute to overcoming the platinum resistance exhibited by most solid tumors, we performed an array of epigenetic approaches, integrating next-generation methodologies and public clinical data to identify new potential epi-biomarkers in ovarian cancer, which is considered the most devastating of gynecological malignancies. METHODS: We cross-analyzed data from methylome assessments...

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Share to Adaptor Proteins, Signal Transducing
Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Epigenesis, Genetic

Share to Ovarian Neoplasms

Share to PAX9 Transcription Factor

Share to Platinum Compounds

Source

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Identifiers

PMID: 34454589
DOI: 10.1186/s13148-021-01149-8
PMCID: PMC8401184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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