Article

An investigation into the contribution of flavin containing monooxygenases to the development and prevention of thiourea-induced pulmonary toxicity in the rat

2013-01-01

Abstract excerpt

NR678, a small thiourea-based rodenticide candidate, is lethal to rats when administered orally at relatively small doses (5 and 10 mg/kg) and causes rapid life-threatening respiratory impairment, characterised by severe hydrothorax and pulmonary oedema. However, rats are protected from a normally lethal dose of NR678, after prior exposure to a low dose (0.5 mg/kg). Similar to other molecules containing the thiour...

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Literature Corpus work: 38706577-fe12-5f3b-9a67-37b9c56391eb
DOI: 10.17638/00017733

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