Article

Drosophila Pyruvate Kinase Links Metabolic State with Circadian Output via TARANIS and PDF

2025-08-21

Abstract excerpt

The circadian clock generates ∼24-hour rhythms that anticipate daily environmental changes. Circadian clock and glucose metabolism are tightly interconnected, and both are disrupted in aging and disease. To examine how glucose hypometabolism impacts circadian rhythm, we downregulated glycolytic enzymes - Hexokinase - C ( Hex - C ), Phosphofructokinase ( Pfk ), and Pyruvate kinase ( Pyk ) - in Drosophila c...

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Literature Corpus work: 38678e35-6d64-5b4d-bb5c-795437b77f6d
DOI: 10.1101/2025.08.18.670854

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