Article

Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle

2023-11-02

Abstract excerpt

Rhythmicity is a cornerstone of behavioral and biological processes, especially metabolism, yet the mechanisms behind metabolite cycling remain elusive. This study uncovers a robust oscillation in key metabolite pathways downstream of glucose in humans. A purpose-built 13 C 6 -glucose isotope tracing platform was used to sample Drosophila every 4h and probe these pathways, revealing a striking peak in biosynthe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44956b88-1c28-50f3-bc00-68986d20e649
DOI: 10.1101/2023.10.30.564837

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycleDOI 10.1101/2023.10.30.564837Read

Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster.Semantic proximity Read

Circadian clock gates diurnal glucose utilization.Semantic proximity Read

Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models in DrosophilaSemantic proximity Read

The polyol pathway is a crucial glucose sensor in <i>Drosophila</i>Semantic proximity Read

Direct quantification of the metabolic heat output of individual <i>Drosophila</i> brainsSemantic proximity Read

Drosophila as a toolkit to tackle cancer and its metabolismSemantic proximity Read

Drosophila Pyruvate Kinase Links Metabolic State with Circadian Output via TARANIS and PDFSemantic proximity Read

The polyol pathway is an evolutionarily conserved system for sensing glucose uptakeSemantic proximity Read

Contribution of Drosophila TRPA1 to Metabolism.Semantic proximity Read

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.Semantic proximity Read

The HuMet Repository: Watching human metabolism at workSemantic proximity Read

A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation.Semantic proximity Read