Article

PD-1 immune checkpoint blockade enhances FLOT chemotherapy toxicity in oesophageal adenocarcinoma cells via immune-independent mechanisms

2021-10-25

Abstract excerpt

Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in several cancer-types including oesophageal adenocarcinoma (OAC). However, the signalling pathways mediating chemotherapy-induced IC upregulation and the mechanisms employed by ICs to protect OAC cells against chemotherapy remain unknown.Longitudi...

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Literature Corpus work: dab34c55-e781-5e10-8593-ee4025764097
DOI: 10.21203/rs.3.rs-1000619/v1

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