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Investigations of survivin: the past, present and future

28 Nov 2010

Abstract excerpt

Survivin is a member of the inhibitors-of-apoptosis protein (IAPs) family. It promotes cell survival through interference with multiple cell cycle-related proteins such as INCENP and Aurora B kinase. Survivin also inhibits cell death through interference with both caspase-dependent and -independent cell apoptosis. Interestingly, recent evidence suggests that survivin may also play a role in the regulation of...

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PMID: 21196211
DOI: 10.2741/3728

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