Article

PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling

2022-08-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Increased infiltration of T cells into ovarian tumors has been repeatedly shown to be predictive of enhanced patient survival. However, despite the evidence of an active immune response in ovarian cancer (OC), the frequency of responses to immune checkpoint blockade (ICB) therapy in OC is much lower than other cancer types. Recent studies have highlighted that deficiencies i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f09479ab-cf08-5e2e-b52e-4f796ffd2012
DOI: 10.1101/2022.08.25.505192

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signalingDOI 10.1101/2022.08.25.505192Read

Downregulated expression of INPP4B contributes to ovarian cancer growth and immune cell infiltrationSemantic proximity Read

The Immunological Role of CDK4/6 and Potential Mechanism Exploration in Ovarian CancerSemantic proximity Read

PPP2R1A mutations portend improved survival after cancer immunotherapy.Semantic proximity Read

Ovarian Cancer in the Era of Immune Checkpoint Inhibitors: State of the Art and Future Perspectives.Semantic proximity Read

The role of PPP2R1A variants in gynecologic malignancies: a paradigm shift in immuno-oncology.Semantic proximity Read

PARP inhibitor and immune checkpoint inhibitor may have synergism efficacy in gallbladder cancerSemantic proximity Read

Eliciting OTUD3/RIPK-Dependent Necroptosis to Prevent Epithelial Ovarian CancerSemantic proximity Read

Inhibition of PTK6 Hinders the Growth and Migration of Ovarian Cancer and Its Potential Clinical SignificanceSemantic proximity Read

Survivin inhibition induces PD-L1 expression through cGAS stabilization and attenuates antitumor immunitySemantic proximity Read

PARP inhibitor and immune checkpoint inhibitor have synergism efficacy in gallbladder cancer.Semantic proximity Read

Inflammation and Immune Escape in Ovarian Cancer: Pathways and Therapeutic OpportunitiesSemantic proximity Read

PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancerSemantic proximity Read