Article
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.
Annals of neurology - 1 Jul 2021
Lai Dongbing, Alipanahi Babak, Fontanillas Pierre, Schwantes-An Tae-Hwi, Aasly Jan, Alcalay Roy N, Beecham Gary W, Berg Daniela, Bressman Susan, Brice Alexis, Brockman Kathrin, Clark Lorraine, Cookson Mark, Das Sayantan, Van Deerlin Vivianna, Follett Jordan, Farrer Matthew J, Trinh Joanne, Gasser Thomas, Goldwurm Stefano, Gustavsson Emil, Klein Christine, Lang Anthony E, Langston J William, Latourelle Jeanne, Lynch Timothy, Marder Karen, Marras Connie, Martin Eden R, McLean Cory Y, Mejia-Santana Helen, Molho Eric, Myers Richard H, Nuytemans Karen, Ozelius Laurie, Payami Haydeh, Raymond Deborah, Rogaeva Ekaterina, Rogers Michael P, Ross Owen A, Samii Ali, Saunders-Pullman Rachel, Schüle Birgitt, Schulte Claudia, Scott William K, Tanner Caroline, Tolosa Eduardo, Tomkins James E, Vilas Dolores, Trojanowski John Q, Uitti Ryan, Vance Jeffery M, Visanji Naomi P, Wszolek Zbigniew K, Zabetian Cyrus P, Mirelman Anat, Giladi Nir, Orr Urtreger Avi, Cannon Paul, Fiske Brian, Foroud Tatiana
Abstract excerpt
OBJECTIVE: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. METHODS: We performed the first genomewide association study of penetrance and age-at-onset of Parkinson's disease in LRRK2 mutation carriers (776 cases and 1,103 non-cases at their last evaluation). Cox proportional hazard models and linear...
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