Article

Dengue virus exploits the host tRNA epitranscriptome to promote viral replication

2023-11-06

Abstract excerpt

The 40-50 RNA modifications of the epitranscriptome regulate posttranscriptional gene expression. Here we show that flaviviruses hijack the host tRNA epitranscriptome to promote expression of pro-viral proteins, with tRNA-modifying ALKBH1 acting as a host restriction factor in dengue virus infection. Early in the infection of human Huh-7 cells, ALKBH1 and its tRNA products 5-formylcytidine (f 5 C) and 2’- O -met...

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Literature Corpus work: 098f2e80-226d-51b9-9b34-c0eabc66d23b
DOI: 10.1101/2023.11.05.565734

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