Article

Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models

2022-05-19

Abstract excerpt

Triple negative breast cancer (TNBC) accounts for over 30% of all breast cancer-related deaths, despite accounting for only 10%–15% of total breast cancer cases. Targeted therapy development has largely stalled in TNBC, underlined by a lack of traditionally druggable addictions like receptor tyrosine kinases (RTKs). Here, through full genome CRISPR/Cas9 screening of TNBC models, we have uncovered the sensitivity o...

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Literature Corpus work: 384203a7-eef1-5152-829d-89e9f54f7453
DOI: 10.1101/2022.05.17.491908

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