Article

Dual Epigenetic and Chaperone Inhibition Disrupts Hypoxia Signaling and Tumor Progression in 3-D Models of Triple-Negative Breast Cancer

2026-07-20

Abstract excerpt

<title>Abstract</title> <p>Therapeutic resistance remains a major barrier to treating aggressive breast cancers, particularly triple-negative breast cancer (TNBC), in which hypoxia-associated stress adaptation within the tumor microenvironment limits treatment efficacy. Here, we investigated a multi-targeted therapeutic strategy combining histone deacetylase (HDAC) inhibition with blockade of hypoxia-associated c...

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Literature Corpus work: 0f67626d-7b94-5710-b865-3a1b9aa96960
DOI: 10.21203/rs.3.rs-10319464/v1

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