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Article

HSPA8 globally modulates transcriptome profile and PI3K/AKT signaling pathway to facilitate malignant progression phenotypes of triple-negative breast cancer.

Science progress - 1 Jan 2026

Xu Wenting, Li Yongtao, Wang Hu, Zhang Chenguang, Zhang Miaomiao, Ou Jianghua

Abstract excerpt

ObjectiveTriple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer. HSPA8 is a chaperone protein involved in the proper folding or degradation of many proteins that are implicated in various types of cancers, while its role in TNBC remains unclear.MethodsIn this study, we extensively explored the cellular function and molecular targets of HSPA8 in TNBC cells by performing small...

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Identifiers

PMID: 42622565
DOI: 10.1177/00368504261480972
PMCID: PMC13494295

Genes

HSPA8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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