Article

Determination of ERG(+), EZH2, NKX3.1, and SPINK-1 Subtypes to Evaluate Their Association With Clonal Origin and Disease Progression in Multifocal Prostate Cancer

2022-01-17

Abstract excerpt

<h4>Background: </h4> The prognostic relevance of prostate cancer (PCa) molecular subtypes remains controversial, given the presence of multiple foci, with the possibility of different subtypes, in the same PCa patient. To help elucidate the clonal origin of heterogeneity in PCa and its association with disease progression, SPOP, ERG(+), EZH2, NKX3.1, and SPINK-1 subtypes were analyzed.MethodsEighty-three samples...

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Literature Corpus work: 383878a3-9ac4-5742-a812-1db40f6332c7
DOI: 10.21203/rs.3.rs-1193535/v1

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