Surface-modified protein crowders influence mutant huntingtin exon 1 aggregation via crowding effects, crowder association, and crowder solution stability.

Abstract excerpt

Intracellular protein aggregation occurs in a highly crowded environment. The intracellular environment is highly heterogeneous, featuring diverse crowder protein surface chemistries along with varying crowder stability and solubility. It remains unclear how these aspects influence protein aggregation. Therefore, we assessed how a crowder protein and its surface properties impact aggregation. We utilize high...

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