Article

Non-targeting control for MISSION <sup>®</sup> shRNA library silences <i>SNRPD3</i> leading to cell death or permanent growth arrest

2020-11-26

Abstract excerpt

In parallel with the expansion of RNA interference techniques evidence has been accumulating that RNAi analyses may be seriously biased due to off-target effects of gene-specific shRNAs. Our work points to another possible source of misinterpretations of shRNA-based data – off-target effects of non-targeting shRNA. We found that one such control for the MISSION ® library (commercialized TRC library), SHC016, is c...

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Literature Corpus work: 3826607b-ad5e-5b25-9bb1-bbac89dab08b
DOI: 10.1101/2020.11.25.398354

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Non-targeting control for MISSION <sup>®</sup> shRNA library silences <i>SNRPD3</i> leading to cell death or permanent growth arrestDOI 10.1101/2020.11.25.398354Read

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