Article

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

2018-01-12

Abstract excerpt

Trinucleotide repeat (TNR) expansions in the genome cause a number of degenerative diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin (HTT) gene responsible for Huntington’s disease (HD). Pathology is caused by protein and RNA generated from the TNR regions including small siRNA-sized repeat fragments. An inverse correlation between the length of the repeats in HTT and cancer incidence...

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Literature Corpus work: 95fe69fe-807d-55ef-8da9-216bd05ddce4
DOI: 10.1101/247429

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