Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers.

doi:10.1002/path.4223

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Article

Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion-positive prostate cancers.

The Journal of pathology - 1 Sept 2013

Krohn Antje, Seidel Annemarie, Burkhardt Lia, Bachmann Frederic, Mader Malte, Grupp Katharina, Eichenauer Till, Becker Andreas, Adam Meike, Graefen Markus, Huland Hartwig, Kurtz Stefan, Steurer Stefan, Tsourlakis Maria C, Minner Sarah, Michl Uwe, Schlomm Thorsten, Sauter Guido, Simon Ronald, Sirma Hüseyin

Abstract excerpt

Deletion of 3p13 has been reported from about 20% of prostate cancers. The clinical significance of this alteration and the tumour suppressor gene(s) driving the deletion remain to be identified. We have mapped the 3p13 deletion locus using SNP array analysis and performed fluorescence in situ hybridization (FISH) analysis to search for associations between 3p13 deletion, prostate cancer phenotype and patient...

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Identifiers

PMID: 23794398
DOI: 10.1002/path.4223

Genes

ERG
FOXP1
PTEN
RYBP
SHQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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