Causal relationships of circulating Gal-3 levels to osteoarthritis risk: a Mendelian randomized study

Abstract excerpt

<h4>Background: </h4> Numerous animal and in vitro human chondrocyte studies have highlighted galectin-3 (Gal-3) as a risk factor for osteoarthritis (OA), but there is little supporting evidence from human studies. This study used Mendelian randomization (MR) to further explore the relationship between Gal-3 levels in human circulation and OA. <h4>Methods: </h4>: Instrumental variables were obtained from publishe...

Topics

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• Aged
• Apolipoprotein B-100
• Apolipoproteins B
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Osteoarthritis, Hip
• Osteoarthritis, Knee
• Triglycerides

Identifiers and source

Literature Corpus work

3823cc89-ecd2-5624-a384-cdbe53c79c74

DOI

10.21203/rs.3.rs-3423920/v1