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Transcriptome signature of cellular senescence

12 Jun 2019

Abstract excerpt

Cellular senescence, an integral component of aging and cancer, arises in response to diverse triggers, including telomere attrition, macromolecular damage and signaling from activated oncogenes. At present, senescent cells are identified by the combined presence of multiple traits, such as senescence-associated protein expression and secretion, DNA damage and β-galactosidase activity; unfortunately, these traits...

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PMID: 31251810
DOI: 10.1093/nar/gkz555

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