Article

Dynamics of the α2-chimaerin–Rac1 interface in Duane retraction syndrome and computational design of candidate probes

2026-08-02

Abstract excerpt

Duane retraction syndrome (DRS) is an eye movement disorder caused by gain-of-function mutations in CHN1, which encodes α2-chimaerin. Mutations in CHN1 cause excessive Rac1 suppression during axon guidance, but the dynamics of the α2-chimaerin–Rac1 interaction remain largely uncharacterized. We simulated the CHN1– Rac1 complex with all-atom molecular dynamics to characterize this interface. An Ile420–Arg445 hydrop...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3813b962-a48f-5fe6-85a1-f1f8c3c79afa
DOI: 10.64898/2026.07.29.741529

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamics of the α2-chimaerin–Rac1 interface in Duane retraction syndrome and computational design of candidate probesDOI 10.64898/2026.07.29.741529Read

Human CHN1 Mutations Hyperactivate α2-Chimaerin and Cause Duane's Retraction SyndromeSemantic proximity Read

<i>In Silico</i> Targeting of Calpain-5 in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV) with Peptides and Natural ProductsSemantic proximity Read

A Computational Foundation Toward Targeting the ELMO1/DOCK2 ComplexSemantic proximity Read

Two Novel CHN1 Mutations in 2 Families With Duane Retraction SyndromeSemantic proximity Read

A Multiscale Computational Architecture to Study Signaling Dynamics at Cell-Cell InterfacesSemantic proximity Read

Expansion of the CHN1 strabismus phenotype.Semantic proximity Read

Rational ab initio Design of a Humanized Nanobody against KRAS using the PIA MethodSemantic proximity Read

Computational Design of a De Novo Binder for Claudin-6 (CLDN6)Semantic proximity Read

Uncovering patterns of atomic interactions in static and dynamic structures of proteinsSemantic proximity Read

Molecular dynamics simulation of RAC1 protein and its de novo variants related to developmental disorders.Semantic proximity Read

Rewiring Ancient Residue Interaction Networks Drove the Evolution of Specificity in Steroid Receptors.Semantic proximity Read

Molecular dynamic simulation reveals damaging impact of RAC1 F28L mutation in the switch I region.Semantic proximity Read