Article

<i>In Silico</i> Targeting of Calpain-5 in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV) with Peptides and Natural Products

2026-08-11

Abstract excerpt

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a rare retinal disease caused by gain-of-function mutations in the non-classical calcium-activated cysteine protease calpain-5 (CAPN5). These mutations lower the calcium threshold for catalytic-triad alignment with downstream effects including excessive proteolysis and retinal degeneration, making CAPN5 a therapeutic target. Clinical studies...

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Literature Corpus work: ea21d854-3250-503f-81bf-3898b7928cb0
DOI: 10.64898/2026.08.11.744189

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